Microprocessor depends on hemin to recognize the apical loop of primary microRNA

Microprocessor, which consists of a ribonuclease III DROSHA and its cofactor DGCR8, initiates microRNA (miRNA) maturation by cleaving primary miRNA transcripts (pri-miRNAs). We recently demonstrated that the DGCR8 dimer recognizes the apical elements of pri-miRNAs, including the UGU motif, to accura...

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Detalles Bibliográficos
Autores principales: Nguyen, Tuan Anh, Park, Joha, Dang, Thi Lieu, Choi, Yeon-Gil, Kim, V Narry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009577/
https://www.ncbi.nlm.nih.gov/pubmed/29750274
http://dx.doi.org/10.1093/nar/gky248

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009577/
https://www.ncbi.nlm.nih.gov/pubmed/29750274
http://dx.doi.org/10.1093/nar/gky248

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