The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer

The HSF and FOXO families of transcription factors play evolutionarily conserved roles in stress resistance and lifespan. In humans, the rs2802292 G-allele at FOXO3 locus has been associated with longevity in all human populations tested; moreover, its copy number correlated with reduced frequency o...

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Detalles Bibliográficos
Autores principales: Grossi, Valentina, Forte, Giovanna, Sanese, Paola, Peserico, Alessia, Tezil, Tugsan, Lepore Signorile, Martina, Fasano, Candida, Lovaglio, Rosaura, Bagnulo, Rosanna, Loconte, Daria C, Susca, Francesco C, Resta, Nicoletta, Simone, Cristiano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009585/
https://www.ncbi.nlm.nih.gov/pubmed/29733381
http://dx.doi.org/10.1093/nar/gky331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009585/
https://www.ncbi.nlm.nih.gov/pubmed/29733381
http://dx.doi.org/10.1093/nar/gky331

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