RNA–DNA and DNA–DNA base-pairing at the upstream edge of the transcription bubble regulate translocation of RNA polymerase and transcription rate

Translocation of RNA polymerase (RNAP) along DNA may be rate-limiting for transcription elongation. The Brownian ratchet model posits that RNAP rapidly translocates back and forth until the post-translocated state is stabilized by NTP binding. An alternative model suggests that RNAP translocation is...

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Detalles Bibliográficos
Autores principales: KIreeva, Maria, Trang, Cyndi, Matevosyan, Gayane, Turek-Herman, Joshua, Chasov, Vitaly, Lubkowska, Lucyna, Kashlev, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009650/
https://www.ncbi.nlm.nih.gov/pubmed/29771376
http://dx.doi.org/10.1093/nar/gky393

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009650/
https://www.ncbi.nlm.nih.gov/pubmed/29771376
http://dx.doi.org/10.1093/nar/gky393

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