DNA-mediated dimerization on a compact sequence signature controls enhancer engagement and regulation by FOXA1

FOXA1 is a transcription factor capable to bind silenced chromatin to direct context-dependent cell fate conversion. Here, we demonstrate that a compact palindromic DNA element (termed ‘DIV’ for its diverging half-sites) induces the homodimerization of FOXA1 with strongly positive cooperativity. Alt...

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Detalles Bibliográficos
Autores principales: Wang, Xuecong, Srivastava, Yogesh, Jankowski, Aleksander, Malik, Vikas, Wei, Yuanjie, del Rosario, Ricardo CH, Cojocaru, Vlad, Prabhakar, Shyam, Jauch, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009666/
https://www.ncbi.nlm.nih.gov/pubmed/29669022
http://dx.doi.org/10.1093/nar/gky259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009666/
https://www.ncbi.nlm.nih.gov/pubmed/29669022
http://dx.doi.org/10.1093/nar/gky259

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