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APE1 deficiency promotes cellular senescence and premature aging features

Base excision repair (BER) handles many forms of endogenous DNA damage, and apurinic/apyrimidinic endonuclease 1 (APE1) is central to this process. Deletion of both alleles of APE1 (a.k.a. Apex1) in mice leads to embryonic lethality, and deficiency in cells can promote cell death. Unlike most other...

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Detalles Bibliográficos
Autores principales: Li, Mengxia, Yang, Xiao, Lu, Xianfeng, Dai, Nan, Zhang, Shiheng, Cheng, Yi, Zhang, Lei, Yang, Yuxin, Liu, Yie, Yang, Zhenzhou, Wang, Dong, Wilson, David M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009672/
https://www.ncbi.nlm.nih.gov/pubmed/29750271
http://dx.doi.org/10.1093/nar/gky326