Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails

Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC 4.2.1.1), herein, we propose an investigation on four physiologically important human (h) CAs (hCA I, II, IV, and IX) with N(1)-substituted seconda...

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Detalles Bibliográficos
Autores principales: Awadallah, Fadi M., Bua, Silvia, Mahmoud, Walaa R., Nada, Hossam H., Nocentini, Alessio, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009853/
https://www.ncbi.nlm.nih.gov/pubmed/29536779
http://dx.doi.org/10.1080/14756366.2018.1446432

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009853/
https://www.ncbi.nlm.nih.gov/pubmed/29536779
http://dx.doi.org/10.1080/14756366.2018.1446432

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