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Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors

GH20 human β-N-acetylhexosaminidases (hsHex) and GH84 human O-GlcNAcase (hOGA) are involved in numerous pathological processes and emerged as promising targets for drug discovery. Based on the catalytic mechanism and structure of the catalytic domains of these β-N-acetylhexosaminidases, a series of...

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Detalles Bibliográficos
Autores principales: Shen, Shengqiang, Chen, Wei, Dong, Lili, Yang, Qing, Lu, Huizhe, Zhang, Jianjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009855/
https://www.ncbi.nlm.nih.gov/pubmed/29390898
http://dx.doi.org/10.1080/14756366.2017.1419217