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Design and synthesis of naphthalimide group-bearing thioglycosides as novel β-N-acetylhexosaminidases inhibitors

GH20 human β-N-acetylhexosaminidases (hsHex) and GH84 human O-GlcNAcase (hOGA) are involved in numerous pathological processes and emerged as promising targets for drug discovery. Based on the catalytic mechanism and structure of the catalytic domains of these β-N-acetylhexosaminidases, a series of...

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Detalles Bibliográficos
Autores principales:	Shen, Shengqiang, Chen, Wei, Dong, Lili, Yang, Qing, Lu, Huizhe, Zhang, Jianjun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009855/ https://www.ncbi.nlm.nih.gov/pubmed/29390898 http://dx.doi.org/10.1080/14756366.2017.1419217

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