Open saccharin-based secondary sulfonamides as potent and selective inhibitors of cancer-related carbonic anhydrase IX and XII isoforms

A large number of novel secondary sulfonamides based on the open saccharin scaffold were synthesized and evaluated as selective inhibitors of four different isoforms of human carbonic anhydrase (hCA I, II, IX and XII, EC 4.2.1.1). They were obtained by reductive ring opening of the newly synthesized...

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Detalles Bibliográficos
Autores principales: D’Ascenzio, Melissa, Guglielmi, Paolo, Carradori, Simone, Secci, Daniela, Florio, Rosalba, Mollica, Adriano, Ceruso, Mariangela, Akdemir, Atilla, Sobolev, Anatoly P., Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009879/
https://www.ncbi.nlm.nih.gov/pubmed/27784170
http://dx.doi.org/10.1080/14756366.2016.1235040

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009879/
https://www.ncbi.nlm.nih.gov/pubmed/27784170
http://dx.doi.org/10.1080/14756366.2016.1235040

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