Molecular modelling insights into a physiologically favourable approach to eicosanoid biosynthesis inhibition through novel thieno[2,3-b]pyridine derivatives

In this research, we exploited derivatives of thieno[2,3-b]pyridine as dual inhibitors of the key enzymes in eicosanoid biosynthesis, cyclooxygenase (COX, subtypes 1 and 2) and 5-lipoxygensase (5-LOX). Testing these compounds in a rat paw oedema model revealed potency higher than ibuprofen. The most...

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Detalles Bibliográficos
Autores principales: Mohamed, Mosaad S., Mansour, Yara E., Amin, Hatem K., El-Araby, Moustafa E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009894/
https://www.ncbi.nlm.nih.gov/pubmed/29651867
http://dx.doi.org/10.1080/14756366.2018.1457657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009894/
https://www.ncbi.nlm.nih.gov/pubmed/29651867
http://dx.doi.org/10.1080/14756366.2018.1457657

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