Cargando…
Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice
The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), o...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009900/ https://www.ncbi.nlm.nih.gov/pubmed/28095711 http://dx.doi.org/10.1080/14756366.2016.1252760 |
_version_ | 1783333485584318464 |
---|---|
author | Astigiano, Simonetta Puglisi, Andrea Mastracci, Luca Fais, Stefano Barbieri, Ottavia |
author_facet | Astigiano, Simonetta Puglisi, Andrea Mastracci, Luca Fais, Stefano Barbieri, Ottavia |
author_sort | Astigiano, Simonetta |
collection | PubMed |
description | The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO(3) in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC. |
format | Online Article Text |
id | pubmed-6009900 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-60099002018-07-11 Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice Astigiano, Simonetta Puglisi, Andrea Mastracci, Luca Fais, Stefano Barbieri, Ottavia J Enzyme Inhib Med Chem Short Communication The microenvironment of solid tumours is extremely acidic and this condition arises since the precancerous stage. This acidic milieu could therefore provide a useful target for both prophylactic and therapeutic approaches. In TRAMP transgenic mice, an in vivo model of prostate adenocarcinoma (AC), oral administration of alkaline water was devoid of unwanted side effects, and when started from an early age was as effective as NaHCO(3) in significantly delaying tumour progression, while when started when prostate tumours were already present, a nonstatistically significant trend in the same direction was detected. These findings indicate that the use of alkalinizing drugs should be considered for chemoprevention and, in association with standard chemotherapy, for treatment of human prostate AC. Taylor & Francis 2017-01-17 /pmc/articles/PMC6009900/ /pubmed/28095711 http://dx.doi.org/10.1080/14756366.2016.1252760 Text en © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group http://creativecommons.org/Licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/Licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Short Communication Astigiano, Simonetta Puglisi, Andrea Mastracci, Luca Fais, Stefano Barbieri, Ottavia Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice |
title | Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice |
title_full | Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice |
title_fullStr | Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice |
title_full_unstemmed | Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice |
title_short | Systemic alkalinisation delays prostate cancer cell progression in TRAMP mice |
title_sort | systemic alkalinisation delays prostate cancer cell progression in tramp mice |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009900/ https://www.ncbi.nlm.nih.gov/pubmed/28095711 http://dx.doi.org/10.1080/14756366.2016.1252760 |
work_keys_str_mv | AT astigianosimonetta systemicalkalinisationdelaysprostatecancercellprogressionintrampmice AT puglisiandrea systemicalkalinisationdelaysprostatecancercellprogressionintrampmice AT mastracciluca systemicalkalinisationdelaysprostatecancercellprogressionintrampmice AT faisstefano systemicalkalinisationdelaysprostatecancercellprogressionintrampmice AT barbieriottavia systemicalkalinisationdelaysprostatecancercellprogressionintrampmice |