Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors

New coumaryl-carboxamide derivatives with the thiourea moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms hCA I, II, VII and IX were evaluated. While the hCA I, II and VII isofo...

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Detalles Bibliográficos
Autores principales: Zengin Kurt, Belma, Sonmez, Fatih, Durdagi, Serdar, Aksoydan, Busecan, Ekhteiari Salmas, Ramin, Angeli, Andrea, Kucukislamoglu, Mustafa, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009903/
https://www.ncbi.nlm.nih.gov/pubmed/28776440
http://dx.doi.org/10.1080/14756366.2017.1354857

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009903/
https://www.ncbi.nlm.nih.gov/pubmed/28776440
http://dx.doi.org/10.1080/14756366.2017.1354857

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