Cargando…

Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors

New coumaryl-carboxamide derivatives with the thiourea moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and their inhibitory activity against the human carbonic anhydrase (hCA) isoforms hCA I, II, VII and IX were evaluated. While the hCA I, II and VII isofo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zengin Kurt, Belma, Sonmez, Fatih, Durdagi, Serdar, Aksoydan, Busecan, Ekhteiari Salmas, Ramin, Angeli, Andrea, Kucukislamoglu, Mustafa, Supuran, Claudiu T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009903/ https://www.ncbi.nlm.nih.gov/pubmed/28776440 http://dx.doi.org/10.1080/14756366.2017.1354857

Ejemplares similares

Investigation of Inhibition Mechanism of Chemokine Receptor CCR5 by Micro-second Molecular Dynamics Simulations
por: Salmas, Ramin Ekhteiari, et al.
Publicado: (2015)

Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents
por: Zengin Kurt, Belma, et al.
Publicado: (2023)

Discovery of Klotho peptide antagonists against Wnt3 and Wnt3a target proteins using combination of protein engineering, protein–protein docking, peptide docking and molecular dynamics simulations
por: Mirza, Shaher Bano, et al.
Publicado: (2016)

Synthesis and biological evaluation of novel 8-substituted quinoline-2-carboxamides as carbonic anhydrase inhibitors
por: Thacker, Pavitra S., et al.
Publicado: (2019)

Benzamide-4-Sulfonamides Are Effective Human Carbonic Anhydrase I, II, VII, and IX Inhibitors
por: Abdoli, Morteza, et al.
Publicado: (2018)

Investigation on Hydrazonobenzenesulfonamides as Human Carbonic Anhydrase I, II, IX and XII Inhibitors
por: Moi, Davide, et al.
Publicado: (2022)

Carbonic anhydrase IX as a novel candidate in liquid biopsy
por: Ozensoy Guler, Ozen, et al.
Publicado: (2019)

Thiosemicarbazide-Substituted Coumarins as Selective Inhibitors of the Tumor Associated Human Carbonic Anhydrases IX and XII
por: Gumus, Arzu, et al.
Publicado: (2022)

New Sulfanilamide Derivatives Incorporating Heterocyclic Carboxamide Moieties as Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2021)

Recent Developments in Targeting Carbonic Anhydrase IX for Cancer Therapeutics
por: McDonald, Paul C., et al.
Publicado: (2012)

Selective inhibition of carbonic anhydrase IX and XII by coumarin and psoralen derivatives
por: Meleddu, Rita, et al.
Publicado: (2021)

Synthesis of Sulfonamides Incorporating Piperidinyl-Hydrazidoureido and Piperidinyl-Hydrazidothioureido Moieties and Their Carbonic Anhydrase I, II, IX and XII Inhibitory Activity
por: Moi, Davide, et al.
Publicado: (2022)

Selenium-analogs based on natural sources as cancer-associated carbonic anhydrase isoforms IX and XII inhibitors
por: Astrain-Redin, Nora, et al.
Publicado: (2023)

Novel thiazolidinone-containing compounds, without the well-known sulphonamide zinc-binding group acting as human carbonic anhydrase IX inhibitors
por: Güzel-Akdemir, Özlen, et al.
Publicado: (2018)

A class of carbonic anhydrase IX/XII – selective carboxylate inhibitors
por: Alhameed, Rakia Abd, et al.
Publicado: (2020)

Synthesis and anticancer activity of new benzensulfonamides incorporating s-triazines as cyclic linkers for inhibition of carbonic anhydrase IX
por: Zain-Alabdeen, Abdelrahman I., et al.
Publicado: (2022)

Isocoumarins: a new class of selective carbonic anhydrase IX and XII inhibitors
por: Onyılmaz, Mehmet, et al.
Publicado: (2022)

Carbonic Anhydrase IX Inhibitors as Candidates for Combination Therapy of Solid Tumors
por: Kalinin, Stanislav, et al.
Publicado: (2021)

Synthesis and carbonic anhydrase I, II, VII, and IX inhibition studies with a series of benzo[d]thiazole-5- and 6-sulfonamides
por: Abdoli, Morteza, et al.
Publicado: (2017)

Click chemistry approaches for developing carbonic anhydrase inhibitors and their applications
por: Angeli, Andrea, et al.
Publicado: (2023)

Selective inhibition of carbonic anhydrase IX by sulphonylated 1,2,3-triazole incorporated benzenesulphonamides capable of inducing apoptosis
por: Siwach, Kiran, et al.
Publicado: (2022)

Cancer Therapeutic Targeting of Hypoxia Induced Carbonic Anhydrase IX: From Bench to Bedside
por: McDonald, Paul C., et al.
Publicado: (2022)

Potent and Selective Carboxylic Acid Inhibitors of Tumor-Associated Carbonic Anhydrases IX and XII
por: Cau, Ylenia, et al.
Publicado: (2017)

Synthesis of an acridine orange sulfonamide derivative with potent carbonic anhydrase IX inhibitory action
por: Bragagni, Marco, et al.
Publicado: (2017)

Discovery of novel 1,3-diaryltriazene sulfonamides as carbonic anhydrase I, II, VII, and IX inhibitors
por: Akocak, Suleyman, et al.
Publicado: (2018)

Continued Structural Exploration of Sulfocoumarin as Selective Inhibitor of Tumor-Associated Human Carbonic Anhydrases IX and XII
por: Giovannuzzi, Simone, et al.
Publicado: (2022)

Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II
por: Kuday, Hilal, et al.
Publicado: (2014)

Five-Membered Heterocyclic Sulfonamides as Carbonic Anhydrase Inhibitors
por: Angeli, Andrea, et al.
Publicado: (2023)

Evaluation of the anticancer potential of a sulphonamide carbonic anhydrase IX inhibitor on cervical cancer cells
por: Koyuncu, Ismail, et al.
Publicado: (2019)

Synthesis and biological evaluation of new 3-substituted coumarin derivatives as selective inhibitors of human carbonic anhydrase IX and XII
por: Mahammad Ghouse, Shaik, et al.
Publicado: (2023)

Synthesis, computational studies and assessment of in vitro inhibitory activity of umbelliferon-based compounds against tumour-associated carbonic anhydrase isoforms IX and XII
por: Mancuso, Francesca, et al.
Publicado: (2020)

Novel 8-Substituted Coumarins That Selectively Inhibit Human Carbonic Anhydrase IX and XII
por: Buran, Kerem, et al.
Publicado: (2019)

Synthesis and Biological Evaluation of Coumarin-Linked 4-Anilinomethyl-1,2,3-Triazoles as Potent Inhibitors of Carbonic Anhydrases IX and XIII Involved in Tumorigenesis
por: Thacker, Pavitra S., et al.
Publicado: (2021)

Structural Insights into Carbonic Anhydrase IX Isoform Specificity of Carbohydrate-Based Sulfamates
por: Moeker, Janina, et al.
Publicado: (2014)

Synthesis of a new series of 3-functionalised-1-phenyl-1,2,3-triazole sulfamoylbenzamides as carbonic anhydrase I, II, IV and IX inhibitors
por: Swain, Baijayantimala, et al.
Publicado: (2019)

Sulfocoumarins as dual inhibitors of human carbonic anhydrase isoforms IX/XII and of human thioredoxin reductase
por: Krasavin, Mikhail, et al.
Publicado: (2020)

Discovery of curcumin inspired sulfonamide derivatives as a new class of carbonic anhydrase isoforms I, II, IX, and XII inhibitors
por: Ramya, P. V. Sri, et al.
Publicado: (2017)

3H-1,2-Benzoxaphosphepine 2-oxides as selective inhibitors of carbonic anhydrase IX and XII
por: Pustenko, Aleksandrs, et al.
Publicado: (2022)

4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies
por: Nada, Hossam, et al.
Publicado: (2022)

HDXmodeller: an online webserver for high-resolution HDX-MS with auto-validation
por: Salmas, Ramin Ekhteiari, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3lle8ch8q5dp1kr488g32f7ok6