3D QSAR studies, pharmacophore modeling, and virtual screening of diarylpyrazole–benzenesulfonamide derivatives as a template to obtain new inhibitors, using human carbonic anhydrase II as a model protein

A 3D-QSAR modeling was performed on a series of diarylpyrazole-benzenesulfonamide derivatives acting as inhibitors of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1). The compounds were collected from two datasets with the same scaffold, and utilized as a template for a new pharmacophore model...

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Detalles Bibliográficos
Autores principales: Entezari Heravi, Yeganeh, Sereshti, Hassan, Saboury, Ali Akbar, Ghasemi, Jahan, Amirmostofian, Marzieh, Supuran, Claudiu T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009914/
https://www.ncbi.nlm.nih.gov/pubmed/28317396
http://dx.doi.org/10.1080/14756366.2016.1241781

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009914/
https://www.ncbi.nlm.nih.gov/pubmed/28317396
http://dx.doi.org/10.1080/14756366.2016.1241781

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