Allosteric inhibition of carnosinase (CN1) by inducing a conformational shift

In humans, low serum carnosinase (CN1) activity protects patients with type 2 diabetes from diabetic nephropathy. We now characterized the interaction of thiol-containing compounds with CN1 cysteine residue at position 102, which is important for CN1 activity. Reduced glutathione (GSH), N-acetylcyst...

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Detalles Bibliográficos
Autores principales: Peters, Verena, Schmitt, Claus P., Weigand, Tim, Klingbeil, Kristina, Thiel, Christian, van den Berg, Antje, Calabrese, Vittorio, Nawroth, Peter, Fleming, Thomas, Forsberg, Elisabete, Wagner, Andreas H., Hecker, Markus, Vistoli, Giulio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009930/
https://www.ncbi.nlm.nih.gov/pubmed/28776438
http://dx.doi.org/10.1080/14756366.2017.1355793

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009930/
https://www.ncbi.nlm.nih.gov/pubmed/28776438
http://dx.doi.org/10.1080/14756366.2017.1355793

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