Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma-associated oncogene homologue (Gli) proteins, and at confirming the chemical nature of its bioactive form. GANT61 is...

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Detalles Bibliográficos
Autores principales: Calcaterra, Andrea, Iovine, Valentina, Botta, Bruno, Quaglio, Deborah, D’Acquarica, Ilaria, Ciogli, Alessia, Iazzetti, Antonia, Alfonsi, Romina, Lospinoso Severini, Ludovica, Infante, Paola, Di Marcotullio, Lucia, Mori, Mattia, Ghirga, Francesca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009951/
https://www.ncbi.nlm.nih.gov/pubmed/29338454
http://dx.doi.org/10.1080/14756366.2017.1419221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009951/
https://www.ncbi.nlm.nih.gov/pubmed/29338454
http://dx.doi.org/10.1080/14756366.2017.1419221

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