Cargando…

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma-associated oncogene homologue (Gli) proteins, and at confirming the chemical nature of its bioactive form. GANT61 is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Calcaterra, Andrea, Iovine, Valentina, Botta, Bruno, Quaglio, Deborah, D’Acquarica, Ilaria, Ciogli, Alessia, Iazzetti, Antonia, Alfonsi, Romina, Lospinoso Severini, Ludovica, Infante, Paola, Di Marcotullio, Lucia, Mori, Mattia, Ghirga, Francesca
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009951/ https://www.ncbi.nlm.nih.gov/pubmed/29338454 http://dx.doi.org/10.1080/14756366.2017.1419221

Ejemplares similares

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype
por: Infante, Paola, et al.
Publicado: (2016)

A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth
por: Lospinoso Severini, Ludovica, et al.
Publicado: (2019)

Drug Delivery Systems for Hedgehog Inhibitors in the Treatment of SHH-Medulloblastoma
por: Caimano, Miriam, et al.
Publicado: (2021)

DUBs Activating the Hedgehog Signaling Pathway: A Promising Therapeutic Target in Cancer
por: Bufalieri, Francesca, et al.
Publicado: (2020)

Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch
por: Infante, Paola, et al.
Publicado: (2019)

Green Routes for the Production of Enantiopure Benzylisoquinoline Alkaloids
por: Ghirga, Francesca, et al.
Publicado: (2017)

The hedgehog inhibitor GANT61 sensitizes prostate cancer cells to ionizing radiation both in vitro and in vivo
por: Gonnissen, Annelies, et al.
Publicado: (2016)

Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors?
por: Lospinoso Severini, Ludovica, et al.
Publicado: (2022)

GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway
por: Zhang, Zhihua, et al.
Publicado: (2020)

Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition
por: Miyazaki, Yumi, et al.
Publicado: (2016)

Synthesis, Biosynthesis, and Biological Activity of Diels–Alder Adducts from Morus Genus: An Update
por: Tortora, Carola, et al.
Publicado: (2022)

Design and Synthesis of New Withaferin A Inspired Hedgehog Pathway Inhibitors
por: Bonandi, Elisa, et al.
Publicado: (2021)

Anti‐cancer stem cell activity of a hedgehog inhibitor GANT61 in estrogen receptor‐positive breast cancer cells
por: Kurebayashi, Junichi, et al.
Publicado: (2017)

GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells
por: Bacelar Sacramento de Araújo, Taís, et al.
Publicado: (2020)

Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing’s Sarcoma Tumor Growth
por: Mullard, Mathilde, et al.
Publicado: (2020)

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
por: Infante, Paola, et al.
Publicado: (2015)

The Combination of Particle Irradiation With the Hedgehog Inhibitor GANT61 Differently Modulates the Radiosensitivity and Migration of Cancer Cells Compared to X-Ray Irradiation
por: Konings, Katrien, et al.
Publicado: (2019)

Hedgehog Signal Inhibitor GANT61 Inhibits the Malignant Behavior of Undifferentiated Hepatocellular Carcinoma Cells by Targeting Non-Canonical GLI Signaling
por: Harada, Kensuke, et al.
Publicado: (2020)

MDB-36. SONIDEGIB, GANT61, AND VELIPARIB TREATMENT BOTH ALONE AND IN COMBINATION INCREASES RADIATION SENSITIVITY IN PEDIATRIC SONIC HEDGEHOG MEDULLOBLASTOMA
por: Price, Laura, et al.
Publicado: (2023)

Chiral switches of chloroquine and hydroxychloroquine: potential drugs to treat COVID-19
por: D’Acquarica, Ilaria, et al.
Publicado: (2020)

The Effect of Metformin and GANT61 Combinations on the Radiosensitivity of Prostate Cancer Cells
por: Gonnissen, Annelies, et al.
Publicado: (2017)

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
por: Infante, Paola, et al.
Publicado: (2018)

The Pictet-Spengler Reaction Updates Its Habits
por: Calcaterra, Andrea, et al.
Publicado: (2020)

In vitro and in vivo inhibition of breast cancer cell growth by targeting the Hedgehog/GLI pathway with SMO (GDC-0449) or GLI (GANT-61) inhibitors
por: Benvenuto, Monica, et al.
Publicado: (2016)

Signaling Switching from Hedgehog-GLI to MAPK Signaling Potentially Serves as a Compensatory Mechanism in Melanoma Cell Lines Resistant to GANT-61
por: Piteša, Nikolina, et al.
Publicado: (2023)

GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment
por: Li, Jianlong, et al.
Publicado: (2016)

Widespread Expression of Hedgehog Pathway Components in a Large Panel of Human Tumor Cells and Inhibition of Tumor Growth by GANT61: Implications for Cancer Therapy
por: Réda, Jiri, et al.
Publicado: (2018)

The protective autophagy activated by GANT-61 in MYCN amplified neuroblastoma cells is mediated by PERK
por: Wang, Jing, et al.
Publicado: (2018)

GANT61/BI-847325 combination: a new hope in lung cancer treatment
por: El-Kishky, Abdel Halim M., et al.
Publicado: (2022)

Naturally-Occurring Alkaloids of Plant Origin as Potential Antimicrobials against Antibiotic-Resistant Infections
por: Casciaro, Bruno, et al.
Publicado: (2020)

Inhibition of autophagy potentiates the efficacy of Gli inhibitor GANT-61 in MYCN-amplified neuroblastoma cells
por: Wang, Jing, et al.
Publicado: (2014)

Mitochondria-derived reactive oxygen species drive GANT61-induced mesothelioma cell apoptosis
por: Lim, Chuan Bian, et al.
Publicado: (2015)

Targeting GLI by GANT61 involves mechanisms dependent on inhibition of both transcription and DNA licensing
por: Zhang, Ruowen, et al.
Publicado: (2016)

Unraveling the therapeutic potential of GANT61/Dactolisib combination as a novel prostate cancer modality
por: Youssef, Mohamed, et al.
Publicado: (2022)

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding
por: Agyeman, Akwasi, et al.
Publicado: (2014)

Miss Zilphia Gant
por: Faulkner, William, 1897-1962
Publicado: (1971)

Miss Zilphia Gant
por: Faulkner, William, 1897-1962

Gant on Bladder Diseases
Publicado: (1877)

Nigritanine as a New Potential Antimicrobial Alkaloid for the Treatment of Staphylococcus aureus-Induced Infections
por: Casciaro, Bruno, et al.
Publicado: (2019)

Rational design and synthesis of a novel BODIPY-based probe for selective imaging of tau tangles in human iPSC-derived cortical neurons
por: Soloperto, Alessandro, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_l0i7qs26l0iq6m3g3fq1gs82ft