Cargando…

Novel 1-(2-pyrimidin-2-yl)piperazine derivatives as selective monoamine oxidase (MAO)-A inhibitors

In the present study, a new series of 2-[4-(pyrimidin-2-yl)piperazin-1-yl]-2-oxoethyl 4-substituted piperazine-1-carbodithioate derivatives (2a-n) were synthesized and screened for their monoamine oxidase A and B inhibitory activity. The structures of compounds were elucidated using spectroscopic me...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kaya, Betül, Yurttaş, Leyla, Sağlik, Begüm Nurpelin, Levent, Serkan, Özkay, Yusuf, Kaplancikli, Zafer Asim
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009961/ https://www.ncbi.nlm.nih.gov/pubmed/28097890 http://dx.doi.org/10.1080/14756366.2016.1247054

Ejemplares similares

Design, Synthesis, In Vitro and In Silico Studies of New Thiazolylhydrazine-Piperazine Derivatives as Selective MAO-A Inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of New Thiosemicarbazone Derivative Schiff Bases as Monoamine Oxidase Inhibitory Agents
por: Çavuşoğlu, Betül Kaya, et al.
Publicado: (2017)

Novel Thiosemicarbazone Derivatives: In Vitro and In Silico Evaluation as Potential MAO-B Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2021)

Design and Synthesis of New Benzothiazole Compounds as Selective hMAO-B Inhibitors
por: Ilgın, Sinem, et al.
Publicado: (2017)

Synthesis of New Hydrazone Derivatives for MAO Enzymes Inhibitory Activity
por: Can, Nafiz Öncü, et al.
Publicado: (2017)

Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis and AChE-Inhibitory Activity of New Benzimidazole Derivatives
por: Acar Cevik, Ulviye, et al.
Publicado: (2019)

Design, Synthesis, and Structure–Activity Relationships of Thiazole Analogs as Anticholinesterase Agents for Alzheimer’s Disease
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2020)

Synthesis and Anticancer Activities of Pyrazole–Thiadiazole-Based EGFR Inhibitors
por: Kurban, Berkant, et al.
Publicado: (2023)

Design, Synthesis, and Evaluation of Novel 2H-Benzo[b][1,4]thiazin-3(4H)-one Derivatives as New Acetylcholinesterase Inhibitors
por: Haji Ali, Sazan, et al.
Publicado: (2022)

Synthesis and Anticandidal Activity of New Imidazole-Chalcones
por: Osmaniye, Derya, et al.
Publicado: (2018)

Synthesis and Anticandidal Activity Evaluation of New Benzimidazole-Thiazole Derivatives
por: Kaplancıklı, Zafer Asım, et al.
Publicado: (2017)

Synthesis and AChE Inhibitory Activity of Novel Thiazolylhydrazone Derivatives
por: Osmaniye, Derya, et al.
Publicado: (2019)

Synthesis of Oxadiazole-Thiadiazole Hybrids and Their Anticandidal Activity
por: Levent, Serkan, et al.
Publicado: (2017)

Synthesis, Docking Studies and Biological Activity of New Benzimidazole- Triazolothiadiazine Derivatives as Aromatase Inhibitor
por: Acar Çevik, Ulviye, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of New Cholinesterase Inhibitors for Alzheimer’s Disease
por: Hussein, Weiam, et al.
Publicado: (2018)

Design, synthesis, and evaluation of novel 2-phenylpropionic acid derivatives as dual COX inhibitory-antibacterial agents
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

Design, Synthesis, and Biological Evaluation Studies of Novel Naphthalene-Chalcone Hybrids As Antimicrobial, Anticandidal, Anticancer, and VEGFR-2 Inhibitors
por: Osmaniye, Derya, et al.
Publicado: (2023)

Design, Synthesis, and In Vitro and In Silico Approaches of Novel Indanone Derivatives as Multifunctional Anti-Alzheimer Agents
por: Sağlık, Begüm Nurpelin, et al.
Publicado: (2022)

Synthesis, Antifungal Activities, Molecular Docking and Molecular Dynamic Studies of Novel Quinoxaline-Triazole Compounds
por: Osmaniye, Derya, et al.
Publicado: (2023)

Synthesis, anticancer evaluation and molecular docking studies of new benzimidazole- 1,3,4-oxadiazole derivatives as human topoisomerase types I poison
por: Acar Çevik, Ulviye, et al.
Publicado: (2020)

Design, Synthesis and Biological Evaluation of Novel N-Pyridyl-Hydrazone Derivatives as Potential Monoamine Oxidase (MAO) Inhibitors
por: Turan-Zitouni, Gülhan, et al.
Publicado: (2018)

Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2019)

Synthesis and Evaluation of New 1,3,4-Thiadiazole Derivatives as Potent Antifungal Agents
por: Karaburun, Ahmet Çağrı, et al.
Publicado: (2018)

Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease
por: Karaca, Şevval, et al.
Publicado: (2022)

Investigation of Novel Quinoline–Thiazole Derivatives as Antimicrobial Agents: In Vitro and In Silico Approaches
por: Evren, Asaf Evrim, et al.
Publicado: (2022)

New Benzimidazole-1,2,4-Triazole Hybrid Compounds: Synthesis, Anticandidal Activity and Cytotoxicity Evaluation
por: Karaca Gençer, Hülya, et al.
Publicado: (2017)

The 4-(dimethylaminoalkyl)piperazine inhibitors of α-glucosidase: allosteric enzyme inhibition and identification of interacting chemical groups
por: GHANI, Usman, et al.
Publicado: (2022)

Synthesis of New Benzothiazole Acylhydrazones as Anticancer Agents
por: Osmaniye, Derya, et al.
Publicado: (2018)

Marine natural products with monoamine oxidase (MAO) inhibitory activity
por: Hong, Ahreum, et al.
Publicado: (2020)

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression
por: Kushal, Swati, et al.
Publicado: (2016)

β-Carboline Alkaloids in Soy Sauce and Inhibition of Monoamine Oxidase (MAO)
por: Herraiz, Tomás
Publicado: (2023)

Monoamine Oxidase Inhibitory Constituents of Propolis: Kinetics and Mechanism of Inhibition of Recombinant Human MAO-A and MAO-B
por: Chaurasiya, Narayan D., et al.
Publicado: (2014)

Three Dimensional Pharmacophore Modelling of Monoamine oxidase-A (MAO-A) inhibitors
por: Sairam, Kalapatapu V.V.M., et al.
Publicado: (2007)

Monoamine Oxidases (MAOs) as Privileged Molecular Targets in Neuroscience: Research Literature Analysis
por: Yeung, Andy Wai Kan, et al.
Publicado: (2019)

Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development
por: Aljanabi, Reem, et al.
Publicado: (2021)

Monoamine oxidase-B (MAO-B) inhibitors: implications for disease-modification in Parkinson’s disease
por: Teo, Kay Cheong, et al.
Publicado: (2013)

From warrior genes to translational solutions: novel insights into monoamine oxidases (MAOs) and aggression
por: Mentis, Alexios-Fotios A., et al.
Publicado: (2021)

A Strategy to Employ Clitoria ternatea as a Prospective Brain Drug Confronting Monoamine Oxidase (MAO) Against Neurodegenerative Diseases and Depression
por: Margret, A. Anita, et al.
Publicado: (2015)

Simultaneous engineering of an enzyme's entrance tunnel and active site: the case of monoamine oxidase MAO-N
por: Li, Guangyue, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_jge3stf97l8vku3hjiehajpfc3