Identification of a novel small-molecule Keap1–Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy

A new Keap1–Nrf2 protein–protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and molecular dynamics simulation. ZJ01 could in vitro trigger Nrf2 nuclear translocation, subsequently resultin...

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Detalles Bibliográficos
Autores principales: Jiang, Cheng-Shi, Zhuang, Chun-Lin, Zhu, Kongkai, Zhang, Juan, Muehlmann, Luis Alexandre, Figueiró Longo, João Paulo, Azevedo, Ricardo Bentes, Zhang, Wen, Meng, Ning, Zhang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009974/
https://www.ncbi.nlm.nih.gov/pubmed/29693453
http://dx.doi.org/10.1080/14756366.2018.1461856

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009974/
https://www.ncbi.nlm.nih.gov/pubmed/29693453
http://dx.doi.org/10.1080/14756366.2018.1461856

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