Cargando…

Identification of a novel small-molecule Keap1–Nrf2 PPI inhibitor with cytoprotective effects on LPS-induced cardiomyopathy

A new Keap1–Nrf2 protein–protein interaction (PPI) inhibitor ZJ01 was identified from our compound library by fluorescence polarization assay, surface plasmon resonance, molecular docking and molecular dynamics simulation. ZJ01 could in vitro trigger Nrf2 nuclear translocation, subsequently resultin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jiang, Cheng-Shi, Zhuang, Chun-Lin, Zhu, Kongkai, Zhang, Juan, Muehlmann, Luis Alexandre, Figueiró Longo, João Paulo, Azevedo, Ricardo Bentes, Zhang, Wen, Meng, Ning, Zhang, Hua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009974/ https://www.ncbi.nlm.nih.gov/pubmed/29693453 http://dx.doi.org/10.1080/14756366.2018.1461856

Ejemplares similares

An updated overview on the development of new photosensitizers for anticancer photodynamic therapy
por: Zhang, Juan, et al.
Publicado: (2018)

Editorial: Nanomedicine in Cancer Targeting and Therapy
por: Longo, João Paulo Figueiró, et al.
Publicado: (2021)

Aluminum–phthalocyanine chloride associated to poly(methyl vinyl ether-co-maleic anhydride) nanoparticles as a new third-generation photosensitizer for anticancer photodynamic therapy
por: Muehlmann, Luis Alexandre, et al.
Publicado: (2014)

How has nanomedical innovation contributed to the COVID-19 vaccine development?
por: Figueiró Longo, João Paulo, et al.
Publicado: (2021)

Application of Nanomedicine in Immunotherapy: Recent Advances and Prospects
por: Longo, João Paulo Figueiró, et al.
Publicado: (2023)

Response of Cytoprotective and Detoxifying Proteins to Vanadate and/or Magnesium in the Rat Liver: The Nrf2-Keap1 System
por: Ścibior, Agnieszka, et al.
Publicado: (2021)

Aluminium-phthalocyanine chloride nanoemulsions for anticancer photodynamic therapy: Development and in vitro activity against monolayers and spheroids of human mammary adenocarcinoma MCF-7 cells
por: Muehlmann, Luis Alexandre, et al.
Publicado: (2015)

Mechanisms of Nrf2/Keap1-Dependent Phase II Cytoprotective and Detoxifying Gene Expression and Potential Cellular Targets of Chemopreventive Isothiocyanates
por: Das, Biswa Nath, et al.
Publicado: (2013)

Perspectives on the application of nanotechnology in photodynamic therapy for the treatment of melanoma
por: Monge-Fuentes, Victoria, et al.
Publicado: (2014)

Synthesis and Evaluation of New Potential Benzo[a]phenoxazinium Photosensitizers for Anticancer Photodynamic Therapy
por: Zhang, Juan, et al.
Publicado: (2018)

Bioactive peptides derived from Radix Angelicae sinensis inhibit ferroptosis in HT22 cells through direct Keap1–Nrf2 PPI inhibition
por: Chen, Ban, et al.
Publicado: (2023)

Panaxydol attenuates ferroptosis against LPS-induced acute lung injury in mice by Keap1-Nrf2/HO-1 pathway
por: Li, Jiucui, et al.
Publicado: (2021)

Phloretin Prevents Diabetic Cardiomyopathy by Dissociating Keap1/Nrf2 Complex and Inhibiting Oxidative Stress
por: Ying, Yin, et al.
Publicado: (2018)

Induction of Immunogenic Cell Death by Photodynamic Therapy Mediated by Aluminum-Phthalocyanine in Nanoemulsion
por: Rodrigues, Mosar Corrêa, et al.
Publicado: (2022)

The KEAP1–NRF2 System in Cancer
por: Taguchi, Keiko, et al.
Publicado: (2017)

Keap1/Nrf2 Signaling Pathway
por: Sykiotis, Gerasimos P.
Publicado: (2021)

A Point Mutation at C151 of Keap1 of Mice Abrogates NRF2 Signaling, Cytoprotection in Vitro, and Hepatoprotection in Vivo by Bardoxolone Methyl (CDDO-Me)
por: Gatbonton-Schwager, Tonibelle, et al.
Publicado: (2023)

The emerging role of the Nrf2–Keap1 signaling pathway in cancer
por: Jaramillo, Melba C., et al.
Publicado: (2013)

Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway
por: Liu, Shengnan, et al.
Publicado: (2022)

Design, synthesis and evaluation of novel small molecules acting as Keap1-Nrf2 protein-protein interaction inhibitors
por: Sun, Yunfeng, et al.
Publicado: (2022)

Discovery of Keap1−Nrf2 small−molecule inhibitors from phytochemicals based on molecular docking
por: Li, Maiquan, et al.
Publicado: (2019)

Structural basis of Keap1 interactions with Nrf2
por: Canning, Peter, et al.
Publicado: (2015)

Epigenetic Regulation of NRF2/KEAP1 by Phytochemicals
por: Bhattacharjee, Shamee, et al.
Publicado: (2020)

The KEAP1/NRF2 Signaling Pathway in Keratinization
por: Ishitsuka, Yosuke, et al.
Publicado: (2020)

The KEAP1-NRF2 System and Esophageal Cancer
por: Hirose, Wataru, et al.
Publicado: (2022)

Modulation of NRF2/KEAP1 Signaling in Preeclampsia
por: Tossetta, Giovanni, et al.
Publicado: (2023)

Loss-of-function mutations in KEAP1 drive lung cancer progression via KEAP1/NRF2 pathway activation
por: Gong, Meiling, et al.
Publicado: (2020)

Mathematical modeling reveals quantitative properties of KEAP1-NRF2 signaling
por: Liu, Shengnan, et al.
Publicado: (2021)

Implementation of a High-Throughput Screen for Identifying Small Molecules to Activate the Keap1-Nrf2-ARE Pathway
por: Wu, Kai Connie, et al.
Publicado: (2012)

The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response
por: Dinkova-Kostova, Albena T.
Publicado: (2012)

Clinical Significance of Keap1 and Nrf2 in Oral Squamous Cell Carcinoma
por: Huang, Cong-Fa, et al.
Publicado: (2013)

Four New Benzoylamide Derivatives Isolated from the Seeds of Lepidium apetalum Willd. and Ameliorated LPS-Induced NRK52e Cells via Nrf2/Keap1 Pathway
por: Li, Meng, et al.
Publicado: (2022)

Cytoprotection “gone astray”: Nrf2 and its role in cancer
por: Geismann, Claudia, et al.
Publicado: (2014)

Bailcalin Protects against Diabetic Cardiomyopathy through Keap1/Nrf2/AMPK-Mediated Antioxidative and Lipid-Lowering Effects
por: Li, Ran, et al.
Publicado: (2019)

New Insight on the Cytoprotective/Antioxidant Pathway Keap1/Nrf2/HO-1 Modulation by Ulva intestinalis Extract and Its Selenium Nanoparticles in Rats with Carrageenan-Induced Paw Edema
por: Almukainzi, May, et al.
Publicado: (2023)

KEAP1 and done? Targeting the NRF2 pathway with sulforaphane
por: Dinkova-Kostova, Albena T., et al.
Publicado: (2017)

WDR23 regulates NRF2 independently of KEAP1
por: Lo, Jacqueline Y., et al.
Publicado: (2017)

Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway
por: Hassanein, Emad H. M., et al.
Publicado: (2020)

Nrf2/Keap1/ARE signaling: Towards specific regulation
por: Ulasov, Alexey V., et al.
Publicado: (2022)

The KEAP1-NRF2 System in Healthy Aging and Longevity
por: Matsumaru, Daisuke, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_6v140ghj0dkhf2svhsbvioje3q