Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis

Multifunctional carbamate-type acetylcholinesterase (AChE) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for Alzheimer’s disease (AD). We reported here the design of new carbamates using pharmacophore model strategy to modulate both cholinesterase and...

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Detalles Bibliográficos
Autores principales: Xie, Qiong, Zheng, Zhaoxi, Shao, Biyun, Fu, Wei, Xia, Zheng, Li, Wei, Sun, Jian, Zheng, Wei, Zhang, Weiwei, Sheng, Wei, Zhang, Qihong, Chen, Hongzhuan, Wang, Hao, Qiu, Zhuibai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009976/
https://www.ncbi.nlm.nih.gov/pubmed/28274151
http://dx.doi.org/10.1080/14756366.2016.1265521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6009976/
https://www.ncbi.nlm.nih.gov/pubmed/28274151
http://dx.doi.org/10.1080/14756366.2016.1265521

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