Identification of new allosteric sites and modulators of AChE through computational and experimental tools

Allosteric sites on proteins are targeted for designing more selective inhibitors of enzyme activity and to discover new functions. Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for am...

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Detalles Bibliográficos
Autores principales: Roca, Carlos, Requena, Carlos, Sebastián-Pérez, Víctor, Malhotra, Sony, Radoux, Chris, Pérez, Concepción, Martinez, Ana, Antonio Páez, Juan, Blundell, Tom L., Campillo, Nuria E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010107/
https://www.ncbi.nlm.nih.gov/pubmed/29873262
http://dx.doi.org/10.1080/14756366.2018.1476502

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010107/
https://www.ncbi.nlm.nih.gov/pubmed/29873262
http://dx.doi.org/10.1080/14756366.2018.1476502

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