Benzo[g]quinazolin-based scaffold derivatives as dual EGFR/HER2 inhibitors

Targeting EGFR has proven to be beneficial in the treatment of several types of solid tumours. So, a series of novel 2-(4-oxo-3-(4-sulfamoylphenyl)-3,4-dihydrobenzo[g]quinazolin-2-ylthio)-N-substituted acetamide 5–19 were synthesised from the starting material 4-(2-mercapto-4-oxobenzo[g]quinazolin-3...

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Detalles Bibliográficos
Autores principales: Ghorab, Mostafa M., Alsaid, Mansour S., Soliman, Aiten M., Al-Mishari, Abdullah A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010119/
https://www.ncbi.nlm.nih.gov/pubmed/29098904
http://dx.doi.org/10.1080/14756366.2017.1389922

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010119/
https://www.ncbi.nlm.nih.gov/pubmed/29098904
http://dx.doi.org/10.1080/14756366.2017.1389922

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