Structural re-positioning, in silico molecular modelling, oxidative degradation, and biological screening of linagliptin as adenosine 3 receptor (ADORA3) modulators targeting hepatocellular carcinoma

Chemical entities with structural diversity were introduced as candidates targeting adenosine receptor with different clinical activities, containing 3,7-dihydro-1H-purine-2,6-dione, especially adenosine 3 receptors (ADORA3). Our initial approach started with pharmacophore screening of ADORA3 modula...

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Detalles Bibliográficos
Autores principales: Ayoub, Bassam M., Attia, Yasmeen M., Ahmed, Mahmoud S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010121/
https://www.ncbi.nlm.nih.gov/pubmed/29768061
http://dx.doi.org/10.1080/14756366.2018.1462801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010121/
https://www.ncbi.nlm.nih.gov/pubmed/29768061
http://dx.doi.org/10.1080/14756366.2018.1462801

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