Synthesis and identification of GZD856 as an orally bioavailable Bcr-Abl(T315I) inhibitor overcoming acquired imatinib resistance

Bcr-Abl(T315I) induced drug resistance remains a major challenge to chronic myelogenous leukemia (CML) treatment. Herein, we reported GZD856 as a novel orally bioavailable Bcr-Abl(T315I) inhibitor, which strongly suppressed the kinase activities of both native Bcr-Abl and the T315I mutant with IC(50...

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Detalles Bibliográficos
Autores principales: Lu, Xiaoyun, Zhang, Zhang, Ren, Xiaomei, Wang, Deping, Ding, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010122/
https://www.ncbi.nlm.nih.gov/pubmed/28260399
http://dx.doi.org/10.1080/14756366.2016.1250757

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010122/
https://www.ncbi.nlm.nih.gov/pubmed/28260399
http://dx.doi.org/10.1080/14756366.2016.1250757

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