Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors

New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and in vitro tested as acetylcholinesterase (AChE) inhibitors. 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acetamide (6c, IC(50) value of 43 ...

Descripción completa

Detalles Bibliográficos
Autores principales: Sonmez, Fatih, Zengin Kurt, Belma, Gazioglu, Isil, Basile, Livia, Dag, Aydan, Cappello, Valentina, Ginex, Tiziana, Kucukislamoglu, Mustafa, Guccione, Salvatore
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010140/
https://www.ncbi.nlm.nih.gov/pubmed/28097911
http://dx.doi.org/10.1080/14756366.2016.1250753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010140/
https://www.ncbi.nlm.nih.gov/pubmed/28097911
http://dx.doi.org/10.1080/14756366.2016.1250753

Ejemplares similares