Cargando…

Design, synthesis and docking study of novel coumarin ligands as potential selective acetylcholinesterase inhibitors

New coumaryl-thiazole derivatives with the acetamide moiety as a linker between the alkyl chains and/or the heterocycle nucleus were synthesized and in vitro tested as acetylcholinesterase (AChE) inhibitors. 2-(diethylamino)-N-(4-(2-oxo-2H-chromen-3-yl)thiazol-2-yl)acetamide (6c, IC(50) value of 43 ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sonmez, Fatih, Zengin Kurt, Belma, Gazioglu, Isil, Basile, Livia, Dag, Aydan, Cappello, Valentina, Ginex, Tiziana, Kucukislamoglu, Mustafa, Guccione, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010140/ https://www.ncbi.nlm.nih.gov/pubmed/28097911 http://dx.doi.org/10.1080/14756366.2016.1250753

Ejemplares similares

Anticholinesterase, Antioxidant, Antiaflatoxigenic Activities of Ten Edible Wild Plants from Ordu Area, Turkey
por: Kurt, Belma Zengin, et al.
Publicado: (2018)

Synthesis, biological activity and multiscale molecular modeling studies for coumaryl-carboxamide derivatives as selective carbonic anhydrase IX inhibitors
por: Zengin Kurt, Belma, et al.
Publicado: (2017)

Tail-Approach-Based Design and Synthesis of Coumarin-Monoterpenes as Carbonic Anhydrase Inhibitors and Anticancer Agents
por: Zengin Kurt, Belma, et al.
Publicado: (2023)

Synthesis and In Vitro Inhibition Effect of New Pyrido[2,3-d]pyrimidine Derivatives on Erythrocyte Carbonic Anhydrase I and II
por: Kuday, Hilal, et al.
Publicado: (2014)

Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease
por: Yusufzai, Samina Khan, et al.
Publicado: (2018)

Design, Synthesis and Bioactivity Evaluation of Coumarin–BMT Hybrids as New Acetylcholinesterase Inhibitors
por: Zeng, Fanxin, et al.
Publicado: (2022)

Anti-Alzheimer activity of new coumarin-based derivatives targeting acetylcholinesterase inhibition
por: Kamel, Nahla N., et al.
Publicado: (2023)

Molecular docking based virtual screening of carbonic anhydrase IX with coumarin (a cinnamon compound) derived ligands
por: Meenakumari, Krishnamoorthy, et al.
Publicado: (2019)

Acetylcholinesterase and butyrylcholinesterase inhibitory activities of khellactone coumarin derivatives isolated from Peucedanum japonicum Thurnberg
por: Heo, Jeong Hyun, et al.
Publicado: (2020)

Dual Reversible Coumarin Inhibitors Mutually Bound to Monoamine Oxidase B and Acetylcholinesterase Crystal Structures
por: Ekström, Fredrik, et al.
Publicado: (2022)

Coumarin derivatives as acetyl- and butyrylcholinestrase inhibitors: An in vitro, molecular docking, and molecular dynamics simulations study
por: Abu-Aisheh, Marwa N., et al.
Publicado: (2019)

Acetylcholinesterase-Inhibiting Activity of Salicylanilide N-Alkylcarbamates and Their Molecular Docking
por: Imramovsky, Ales, et al.
Publicado: (2012)

Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies
por: Budryn, Grażyna, et al.
Publicado: (2022)

Molecular docking analysis of acetylcholinesterase inhibitors for Alzheimer's disease management
por: Hakeem, Israa J
Publicado: (2023)

Novel Coumarin-Thiadiazole Hybrids and Their Cu(II) and Zn(II) Complexes as Potential Antimicrobial Agents and Acetylcholinesterase Inhibitors
por: Karcz, Dariusz, et al.
Publicado: (2021)

Lipoxygenase Inhibition Activity of Coumarin Derivatives—QSAR and Molecular Docking Study
por: Lončarić, Melita, et al.
Publicado: (2020)

In vitro acetylcholinesterase inhibition by psoralen using molecular docking and enzymatic studies
por: Somani, Gauresh, et al.
Publicado: (2015)

Unfolding the Antibacterial Activity and Acetylcholinesterase Inhibition Potential of Benzofuran-Triazole Hybrids: Synthesis, Antibacterial, Acetylcholinesterase Inhibition, and Molecular Docking Studies
por: Saeed, Sadaf, et al.
Publicado: (2023)

Discovery of Novel Coumarin-Schiff Base Hybrids as Potential Acetylcholinesterase Inhibitors: Design, Synthesis, Enzyme Inhibition, and Computational Studies
por: Hasan, Aso Hameed, et al.
Publicado: (2023)

Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease
por: Vijayakumar, Subramaniyan, et al.
Publicado: (2018)

Probing the origins of human acetylcholinesterase inhibition via QSAR modeling and molecular docking
por: Simeon, Saw, et al.
Publicado: (2016)

Novel hits for acetylcholinesterase inhibition derived by docking-based screening on ZINC database
por: Doytchinova, Irini, et al.
Publicado: (2018)

Discovery of novel dual-active 3-(4-(dimethylamino)phenyl)-7-aminoalcoxy-coumarin as potent and selective acetylcholinesterase inhibitor and antioxidant
por: de Souza, Gabriela Alves, et al.
Publicado: (2019)

Discovery of Potent Carbonic Anhydrase and Acetylcholinesterase Inhibitors: 2-Aminoindan β-Lactam Derivatives
por: Genç, Hayriye, et al.
Publicado: (2016)

Sequential Application of Ligand and Structure Based Modeling Approaches to Index Chemicals for Their hH(4)R Antagonism
por: Pappalardo, Matteo, et al.
Publicado: (2014)

Probing the origins of aromatase inhibitory activity of disubstituted coumarins via QSAR and molecular docking
por: Worachartcheewan, Apilak, et al.
Publicado: (2014)

Tricyclic coumarin sulphonate derivatives with alkaline phosphatase inhibitory effects: in vitro and docking studies
por: Iqbal, Jamshed, et al.
Publicado: (2018)

Coumarin derivatives bearing benzoheterocycle moiety: synthesis, cholinesterase inhibitory, and docking simulation study
por: Hirbod, Kimia, et al.
Publicado: (2017)

Coumarin–carbazole based functionalized pyrazolines: synthesis, characterization, anticancer investigation and molecular docking
por: Patel, Mrugesh, et al.
Publicado: (2021)

Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies
por: Tariq, Hafiza Zara, et al.
Publicado: (2023)

Synthesis of novel coumarin analogues: Investigation of molecular docking interaction of SARS-CoV-2 proteins with natural and synthetic coumarin analogues and their pharmacokinetics studies
por: Chidambaram, Sathishkumar, et al.
Publicado: (2021)

Modeling of substrates sorption into acetylcholinesterase and butyrylcholinesterase active sites using molecular docking method
por: Belinskaya, Daria, et al.
Publicado: (2008)

Synthesis and molecular docking studies of some 4-phthalimidobenzenesulfonamide derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors
por: Soyer, Zeynep, et al.
Publicado: (2016)

Synthesis, in vitro screening and molecular docking of isoquinolinium-5-carbaldoximes as acetylcholinesterase and butyrylcholinesterase reactivators
por: Malinak, David, et al.
Publicado: (2020)

2D-QSAR and docking study of a series of coumarin derivatives as inhibitors of CDK (anticancer activity) with an application of the molecular docking method
por: Kasmi, Rania, et al.
Publicado: (2020)

In silico molecular docking: Evaluation of coumarin based derivatives against SARS-CoV-2
por: Chidambaram, Sathish Kumar, et al.
Publicado: (2020)

Natural coumarins as potential anti-SARS-CoV-2 agents supported by docking analysis
por: Abdelmohsen, Usama Ramadan, et al.
Publicado: (2021)

Synthesis, docking studies, biological activity of carbon monoxide release molecules based on coumarin derivatives
por: Liu, Huapeng, et al.
Publicado: (2022)

Chemosensing Properties of Coumarin Derivatives: Promising Agents with Diverse Pharmacological Properties, Docking and DFT Investigation
por: Al-Hazmy, Sadeq M., et al.
Publicado: (2022)

Synthesis and Molecular Docking of Some Novel 3-Thiazolyl-Coumarins as Inhibitors of VEGFR-2 Kinase
por: Abolibda, Tariq Z., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_955fm2kbqkrfvoi9pubirc7rbj