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Synthesis of new pyridothienopyrimidinone derivatives as Pim-1 inhibitors
Four series of pyridothienopyrimidin-4-one derivatives were designed and prepared to improve the pim-1 inhibitory activity of the previously reported thieno[2,3-b]pyridines. Significant improvement in the pim-1 inhibition and cytotoxic activity was achieved using structure rigidification strategy vi...
| Hlavní autoři: | , , |
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| Médium: | Online Článek Text |
| Jazyk: | English |
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Taylor & Francis
2017
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| Témata: | |
| On-line přístup: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010143/ https://www.ncbi.nlm.nih.gov/pubmed/28097906 http://dx.doi.org/10.1080/14756366.2016.1261130 |