ARQ-197, a small-molecule inhibitor of c-Met, reduces tumour burden and prevents myeloma-induced bone disease in vivo

The receptor tyrosine kinase c-Met, its ligand HGF, and components of the downstream signalling pathway, have all been implicated in the pathogenesis of myeloma, both as modulators of plasma cell proliferation and as agents driving osteoclast differentiation and osteoblast inhibition thus, all these...

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Detalles Bibliográficos
Autores principales: Lath, Darren L., Buckle, Clive H., Evans, Holly R., Fisher, Matthew, Down, Jenny M., Lawson, Michelle A., Chantry, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010293/
https://www.ncbi.nlm.nih.gov/pubmed/29924867
http://dx.doi.org/10.1371/journal.pone.0199517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010293/
https://www.ncbi.nlm.nih.gov/pubmed/29924867
http://dx.doi.org/10.1371/journal.pone.0199517

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