Downregulation of the neuronal opioid gene expression concomitantly with neuronal decline in dorsolateral prefrontal cortex of human alcoholics

Molecular changes in cortical areas of addicted brain may underlie cognitive impairment and loss of control over intake of addictive substances and alcohol. Prodynorphin (PDYN) gives rise to dynorphin (DYNs) opioid peptides which target kappa-opioid receptor (KOR). DYNs mediate alcohol-induced impai...

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Detalles Bibliográficos
Autores principales: Bazov, Igor, Sarkisyan, Daniil, Kononenko, Olga, Watanabe, Hiroyuki, Karpyak, Victor M., Yakovleva, Tatiana, Bakalkin, Georgy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010434/
https://www.ncbi.nlm.nih.gov/pubmed/29925858
http://dx.doi.org/10.1038/s41398-017-0075-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010434/
https://www.ncbi.nlm.nih.gov/pubmed/29925858
http://dx.doi.org/10.1038/s41398-017-0075-5

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