Human IgM antibody rHIgM22 promotes phagocytic clearance of myelin debris by microglia

In multiple sclerosis (MS), demyelinated CNS lesions fail to sufficiently remyelinate, despite the presence of oligodendrocyte precursor cells (OPCs) capable of differentiating into mature oligodendrocytes. MS lesions contain damaged myelin debris that can inhibit OPC maturation and hinder repair. r...

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Detalles Bibliográficos
Autores principales: Zorina, Yana, Stricker, Jason, Caggiano, Anthony O., Button, Donald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010437/
https://www.ncbi.nlm.nih.gov/pubmed/29925848
http://dx.doi.org/10.1038/s41598-018-27559-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010437/
https://www.ncbi.nlm.nih.gov/pubmed/29925848
http://dx.doi.org/10.1038/s41598-018-27559-y

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