Microenvironment‐induced PIM kinases promote CXCR4‐triggered mTOR pathway required for chronic lymphocytic leukaemia cell migration

Lymph node microenvironment provides chronic lymphocytic leukaemia (CLL) cells with signals promoting their survival and granting resistance to chemotherapeutics. CLL cells overexpress PIM kinases, which regulate apoptosis, cell cycle and migration. We demonstrate that BCR crosslinking, CD40 stimula...

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Detalles Bibliográficos
Autores principales: Białopiotrowicz, Emilia, Górniak, Patryk, Noyszewska‐Kania, Monika, Puła, Bartosz, Makuch‐Łasica, Hanna, Nowak, Grażyna, Bluszcz, Aleksandra, Szydłowski, Maciej, Jabłonska, Ewa, Piechna, Karolina, Sewastianik, Tomasz, Polak, Anna, Lech‐Marańda, Ewa, Budziszewska, Bożena K., Wasylecka‐Juszczyńska, Maja, Borg, Katarzyna, Warzocha, Krzysztof, Czardybon, Wojciech, Gałęzowski, Michał, Windak, Renata, Brzózka, Krzysztof, Juszczyński, Przemysław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010703/
https://www.ncbi.nlm.nih.gov/pubmed/29665227
http://dx.doi.org/10.1111/jcmm.13632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010703/
https://www.ncbi.nlm.nih.gov/pubmed/29665227
http://dx.doi.org/10.1111/jcmm.13632

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