Glucocorticoids modulate multidrug resistance transporters in the first trimester human placenta

The placental multidrug transporters, P‐glycoprotein (P‐gp, encoded by ABCB1) and breast cancer resistance protein (BCRP,ABCG2) protect the foetus from exposure to maternally derived glucocorticoids, toxins and xenobiotics. During pregnancy, maternal glucocorticoid levels can be elevated by stress o...

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Detalles Bibliográficos
Autores principales: Lye, Phetcharawan, Bloise, Enrrico, Nadeem, Lubna, Gibb, William, Lye, Stephen J., Matthews, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010777/
https://www.ncbi.nlm.nih.gov/pubmed/29691980
http://dx.doi.org/10.1111/jcmm.13646

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6010777/
https://www.ncbi.nlm.nih.gov/pubmed/29691980
http://dx.doi.org/10.1111/jcmm.13646

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