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Characterization of Atherosclerosis Formation in a Murine Model of Type IIa Human Familial Hypercholesterolemia

A murine genetic model of LDL-cholesterol- (LDL-C-) driven atherosclerosis, based on complete deficiencies of both the LDL-receptor (Ldlr(−/−)) and key catalytic component of an apolipoprotein B-edisome complex (Apobec1(−/−)), which converts apoB-100 to apoB-48, has been extensively characterized. T...

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Detalles Bibliográficos
Autores principales:	Miyajima, Chiharu, Iwaki, Takayuki, Umemura, Kazuo, Ploplis, Victoria A., Castellino, Francis J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011105/ https://www.ncbi.nlm.nih.gov/pubmed/29977908 http://dx.doi.org/10.1155/2018/1878964

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