Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles

BACKGROUND: The International Mouse Phenotyping Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene–phenotype associations. While CRISPR/Cas9-mediated null allele production in mice is highly efficient, generation of co...

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Detalles Bibliográficos
Autores principales: Lanza, Denise G., Gaspero, Angelina, Lorenzo, Isabel, Liao, Lan, Zheng, Ping, Wang, Ying, Deng, Yu, Cheng, Chonghui, Zhang, Chuansheng, Seavitt, John R., DeMayo, Francesco J., Xu, Jianming, Dickinson, Mary E., Beaudet, Arthur L., Heaney, Jason D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011517/
https://www.ncbi.nlm.nih.gov/pubmed/29925370
http://dx.doi.org/10.1186/s12915-018-0529-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011517/
https://www.ncbi.nlm.nih.gov/pubmed/29925370
http://dx.doi.org/10.1186/s12915-018-0529-0

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