Cargando…

Comparative analysis of single-stranded DNA donors to generate conditional null mouse alleles

BACKGROUND: The International Mouse Phenotyping Consortium is generating null allele mice for every protein-coding gene in the genome and characterizing these mice to identify gene–phenotype associations. While CRISPR/Cas9-mediated null allele production in mice is highly efficient, generation of co...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lanza, Denise G., Gaspero, Angelina, Lorenzo, Isabel, Liao, Lan, Zheng, Ping, Wang, Ying, Deng, Yu, Cheng, Chonghui, Zhang, Chuansheng, Seavitt, John R., DeMayo, Francesco J., Xu, Jianming, Dickinson, Mary E., Beaudet, Arthur L., Heaney, Jason D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011517/ https://www.ncbi.nlm.nih.gov/pubmed/29925370 http://dx.doi.org/10.1186/s12915-018-0529-0

Ejemplares similares

Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice
por: Scharffetter-Kochanek, Karin, et al.
Publicado: (1998)

Performing Parentage Analysis in the Presence of Inbreeding and Null Alleles
por: Huang, Kang, et al.
Publicado: (2018)

Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development
por: Shen, Jieli, et al.
Publicado: (2016)

Generation of mice with a conditional Foxp2 null allele
por: French, Catherine A, et al.
Publicado: (2007)

Characterization of a cdc14 null allele in Drosophila melanogaster
por: Neitzel, Leif R., et al.
Publicado: (2018)

Difference in phenotypic severity of presumed null alleles of capg-1
por: VanDiepenbos, Sarah, et al.
Publicado: (2020)

NullHap – a versatile application to estimate haplotype frequencies from unphased genotypes in the presence of null alleles
por: Nowak, Robert M, et al.
Publicado: (2008)

Scaffold attachment factor B2 (SAFB2)-null mice reveal non-redundant functions of SAFB2 compared with its paralog, SAFB1
por: Jiang, Shiming, et al.
Publicado: (2015)

Association of a null allele of SPRN with variant Creutzfeldt–Jakob disease
por: Beck, J A, et al.
Publicado: (2008)

Generation and functional characterization of a conditional Pumilio2 null allele
por: Lin, Kai-bo, et al.
Publicado: (2018)

Null alleles are ubiquitous at microsatellite loci in the Wedge Clam (Donax trunculus)
por: Rico, Ciro, et al.
Publicado: (2017)

A novel null allele of C. elegans gene ceh-14
por: Bayer, Emily, et al.
Publicado: (2018)

Polymorphism of β-casein in the Creole goat of Guadeloupe: evidence for a null allele
por: Mahé, MF, et al.
Publicado: (1993)

Marker assisted accelerated introgression of null allele of kunitz trypsin inhibitor in soybean
por: Kumar, Vineet, et al.
Publicado: (2015)

Alpha 1 Antitrypsin Deficiency, Two Cases of Heterozygous S and Clayton Null Alleles
por: Rosenbaum, Eric M., et al.
Publicado: (2017)

Null IFNAR1 and IFNAR2 alleles are surprisingly common in the Pacific and Arctic
por: Meyts, Isabelle
Publicado: (2022)

A null allele in the wdfy-3 selective autophagy gene of C. elegans .
por: Buddell, Tyler, et al.
Publicado: (2022)

Three-dimensional microCT imaging of mouse development from early post-implantation to early postnatal stages
por: Hsu, Chih-Wei, et al.
Publicado: (2016)

Targeting the Glucose Regulated Protein-78 (GRP78) abrogates Pten-null driven AKT-activation and endometrioid tumorigenesis
por: Lin, Yvonne G., et al.
Publicado: (2015)

Inference of population structure using multilocus genotype data: dominant markers and null alleles
por: FALUSH, DANIEL, et al.
Publicado: (2007)

Generation and characterization of mice with a conditional null allele of the HtrA4 gene
por: LIU, JU, et al.
Publicado: (2015)

Truncating SOX9 Alterations Are Heterozygous Null Alleles in Genome-Stable Colorectal Cancer
por: DURONIO, G. N., et al.
Publicado: (2022)

Null allele, allelic dropouts or rare sex detection in clonal organisms: simulations and application to real data sets of pathogenic microbes
por: Séré, Modou, et al.
Publicado: (2014)

Genome-wide allele- and strand-specific expression profiling
por: Gagneur, Julien, et al.
Publicado: (2009)

Identification of Null Alleles and Deletions from SNP Genotypes for an Intercross Between Domestic and Wild Chickens
por: Crooks, Lucy, et al.
Publicado: (2013)

APOL1 Null Alleles from a Rural Village in India Do Not Correlate with Glomerulosclerosis
por: Johnstone, Duncan B., et al.
Publicado: (2012)

Frequency of null allele of Human Leukocyte Antigen-G (HLA-G) locus in subjects to recurrent miscarriage
por: Alizadeh, Nazila, et al.
Publicado: (2016)

Delayed skeletal development and IGF-1 deficiency in a mouse model of lysinuric protein intolerance
por: Stroup, Bridget M., et al.
Publicado: (2023)

Association of GSTM1 Null Allele with Prostate Cancer Risk: Evidence from 36 Case-Control Studies
por: Wei, Bingbing, et al.
Publicado: (2012)

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development
por: Davis, Hayley, et al.
Publicado: (2011)

Correction: Characterization of a cdc14 null allele in Drosophila melanogaster (doi:10.1242/bio.035394)
por: Neitzel, Leif, et al.
Publicado: (2018)

Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants.
por: Lins, Jeremy, et al.
Publicado: (2023)

Deletional Alpha-Thalassemia Alleles in Amazon Blood Donors
por: Anselmo, Fernanda Cozendey, et al.
Publicado: (2020)

Robust Genome Editing with Short Single-Stranded and Long, Partially Single-Stranded DNA Donors in Caenorhabditis elegans
por: Dokshin, Gregoriy A., et al.
Publicado: (2018)

C4B null alleles are not associated with genetic polymorphisms in the adjacent gene CYP21A2 in autism
por: Sweeten, Thayne L, et al.
Publicado: (2008)

Identification and physical mapping of a polymorphic human T cell receptor V beta gene with a frequent null allele
Publicado: (1993)

Distribution of MdACS3 null alleles in apple (Malus × domestica Borkh.) and its relevance to the fruit ripening characters
por: Bai, Songling, et al.
Publicado: (2012)

GST M1-T1 null Allele Frequency Patterns in Geographically Assorted Human Populations: A Phylogenetic Approach
por: Kasthurinaidu, Senthilkumar Pitchalu, et al.
Publicado: (2015)

Characterization of a Null Allelic Mutant of the Rice NAL1 Gene Reveals Its Role in Regulating Cell Division
por: Jiang, Dan, et al.
Publicado: (2015)

ABCA4 Variant c.5714+5G>A in Trans With Null Alleles Results in Primary RPE Damage
por: Sajovic, Jana, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_60qf9kf4c3l5kr2r789f45qkd4