Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models

BACKGROUND: Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer clinical application, indicating so...

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Detalles Bibliográficos
Autores principales: Ye, Bingyu, Shen, Wenlong, Shi, Minglei, Zhang, Yan, Xu, Cunshuan, Zhao, Zhihu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PeerJ Inc. 2018
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011820/
https://www.ncbi.nlm.nih.gov/pubmed/29938138
http://dx.doi.org/10.7717/peerj.5043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011820/
https://www.ncbi.nlm.nih.gov/pubmed/29938138
http://dx.doi.org/10.7717/peerj.5043

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