Cargando…
Intein-mediated backbone cyclization of entolimod confers enhanced radioprotective activity in mouse models
BACKGROUND: Entolimod is a Salmonella enterica flagellin derivate. Previous work has demonstrated that entolimod effectively protects mice and non-human primates from ionizing radiation. However, it caused a “flu-like” syndrome after radioprotective and anticancer clinical application, indicating so...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
PeerJ Inc.
2018
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6011820/ https://www.ncbi.nlm.nih.gov/pubmed/29938138 http://dx.doi.org/10.7717/peerj.5043 |