Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm

GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin; a critical regulator of endothelial NO synthase function. We have previously shown that mice with selective loss of Gch1 in endothelial cells have mild vascular dysfunction, but the consequences of en...

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Detalles Bibliográficos
Autores principales: Chuaiphichai, Surawee, Rashbrook, Victoria S., Hale, Ashley B., Trelfa, Lucy, Patel, Jyoti, McNeill, Eileen, Lygate, Craig A., Channon, Keith M., Douglas, Gillian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott, Williams & Wilkins 2018
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012043/
https://www.ncbi.nlm.nih.gov/pubmed/29844152
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012043/
https://www.ncbi.nlm.nih.gov/pubmed/29844152
http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11144

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