Cargando…

Endothelial Cell Tetrahydrobiopterin Modulates Sensitivity to Ang (Angiotensin) II–Induced Vascular Remodeling, Blood Pressure, and Abdominal Aortic Aneurysm

GTPCH (GTP cyclohydrolase 1, encoded by Gch1) is required for the synthesis of tetrahydrobiopterin; a critical regulator of endothelial NO synthase function. We have previously shown that mice with selective loss of Gch1 in endothelial cells have mild vascular dysfunction, but the consequences of en...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chuaiphichai, Surawee, Rashbrook, Victoria S., Hale, Ashley B., Trelfa, Lucy, Patel, Jyoti, McNeill, Eileen, Lygate, Craig A., Channon, Keith M., Douglas, Gillian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott, Williams & Wilkins 2018
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012043/ https://www.ncbi.nlm.nih.gov/pubmed/29844152 http://dx.doi.org/10.1161/HYPERTENSIONAHA.118.11144

Ejemplares similares

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
por: Douglas, Gillian, et al.
Publicado: (2018)

A key role for tetrahydrobiopterin‐dependent endothelial NOS regulation in resistance arteries: studies in endothelial cell tetrahydrobiopterin‐deficient mice
por: Chuaiphichai, Surawee, et al.
Publicado: (2017)

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension()
por: Chuaiphichai, Surawee, et al.
Publicado: (2016)

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation
por: McNeill, Eileen, et al.
Publicado: (2015)

Endothelial GTPCH (GTP Cyclohydrolase 1) and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling, and Fetal Growth
por: Chuaiphichai, Surawee, et al.
Publicado: (2021)

Vascular wall regulator of G-protein signalling-1 (RGS-1) is required for angiotensin II–mediated blood pressure control
por: Patel, Jyoti, et al.
Publicado: (2018)

Endothelial cell-specific roles for tetrahydrobiopterin in myocardial function, cardiac hypertrophy, and response to myocardial ischemia-reperfusion injury
por: Chuaiphichai, Surawee, et al.
Publicado: (2023)

A key role for the novel coronary artery disease gene JCAD in atherosclerosis via shear stress mechanotransduction
por: Douglas, Gillian, et al.
Publicado: (2020)

Isolation and culture of murine bone marrow-derived macrophages for nitric oxide and redox biology
por: Bailey, Jade D., et al.
Publicado: (2020)

A requirement for Gch1 and tetrahydrobiopterin in embryonic development
por: Douglas, Gillian, et al.
Publicado: (2015)

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS): EFFECTS ON TETRAHYDROBIOPTERIN-DEPENDENT CATALYSIS AND eNOS DIMERIZATION
por: Benson, Matthew A., et al.
Publicado: (2013)

Regulation of mycobacterial infection by macrophage Gch1 and tetrahydrobiopterin
por: McNeill, Eileen, et al.
Publicado: (2018)

Nitric Oxide Modulates Metabolic Remodeling in Inflammatory Macrophages through TCA Cycle Regulation and Itaconate Accumulation
por: Bailey, Jade D., et al.
Publicado: (2019)

ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)–Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm
por: Jana, Sayantan, et al.
Publicado: (2020)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
por: Crabtree, Mark J., et al.
Publicado: (2011)

Lysyl hydroxylase 1 (LH1) deficiency promotes angiotensin II (Ang II)-induced dissecting abdominal aortic aneurysm
por: Li, Hao, et al.
Publicado: (2021)

RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling
por: Patel, Jyoti, et al.
Publicado: (2015)

Mast cell tetrahydrobiopterin contributes to itch in mice
por: Zschiebsch, Katja, et al.
Publicado: (2018)

The Downstream Regulation of Chemokine Receptor Signalling: Implications for Atherosclerosis
por: Patel, Jyoti, et al.
Publicado: (2013)

Integrated Redox Sensor and Effector Functions for Tetrahydrobiopterin- and Glutathionylation-dependent Endothelial Nitric-oxide Synthase Uncoupling
por: Crabtree, Mark J., et al.
Publicado: (2013)

Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms
por: Zhang, Yixuan, et al.
Publicado: (2022)

Effect of irradiation and bone marrow transplantation on angiotensin II-induced aortic inflammation in ApoE knockout mice
por: Patel, Jyoti, et al.
Publicado: (2018)

GTP Cyclohydrolase 1/Tetrahydrobiopterin Counteract Ferroptosis through Lipid Remodeling
por: Kraft, Vanessa A. N., et al.
Publicado: (2019)

A novel role for endothelial tetrahydrobiopterin in mitochondrial redox balance
por: Bailey, Jade, et al.
Publicado: (2017)

PHACTR1 modulates vascular compliance but not endothelial function: a translational study
por: Wood, Alice, et al.
Publicado: (2022)

Role of Renin-Angiotensin System Components in Atherosclerosis: Focus on Ang-II, ACE2, and Ang-1–7
por: Silva, Gabriela M., et al.
Publicado: (2020)

Morphological and Biomechanical Differences in the Elastase and AngII apoE (−/−) Rodent Models of Abdominal Aortic Aneurysms
por: Phillips, Evan H., et al.
Publicado: (2015)

Endothelial cell repopulation after stenting determines in-stent neointima formation: effects of bare-metal vs. drug-eluting stents and genetic endothelial cell modification
por: Douglas, Gillian, et al.
Publicado: (2013)

TGF-β Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
por: Chen, Xiaofeng, et al.
Publicado: (2016)

Metabolic Regulation of Adipose Tissue Macrophage Function in Obesity and Diabetes
por: Appari, Mahesh, et al.
Publicado: (2018)

Crucial Role for Neuronal Nitric Oxide Synthase in Early Microcirculatory Derangement and Recipient Survival following Murine Pancreas Transplantation
por: Cardini, Benno, et al.
Publicado: (2014)

Activation of Bone Marrow-Derived Cells Angiotensin (Ang) II Type 1 Receptor by Ang II Promotes Atherosclerotic Plaque Vulnerability
por: Pellegrin, Maxime, et al.
Publicado: (2018)

Elevated Adiponectin Levels Suppress Perivascular and Aortic Inflammation and Prevent AngII-induced Advanced Abdominal Aortic Aneurysms
por: Wågsäter, Dick, et al.
Publicado: (2016)

All-trans retinoic acid attenuates the progression of Ang II-induced abdominal aortic aneurysms in ApoE(−/−)mice
por: Xiao, Jie, et al.
Publicado: (2020)

Kaempferol Prevents Against Ang II-induced Cardiac Remodeling Through Attenuating Ang II-induced Inflammation and Oxidative Stress
por: Du, Yao, et al.
Publicado: (2019)

Roxadustat prevents Ang II hypertension by targeting angiotensin receptors and eNOS
por: Yu, Jing, et al.
Publicado: (2021)

Tetrahydrobiopterin Protects Against Hypertrophic Heart Disease Independent of Myocardial Nitric Oxide Synthase Coupling
por: Hashimoto, Toru, et al.
Publicado: (2016)

Central Tetrahydrobiopterin Concentration in Neurodevelopmental Disorders
por: Frye, Richard E.
Publicado: (2010)

Modulation of Radiation Response by the Tetrahydrobiopterin Pathway
por: Pathak, Rupak, et al.
Publicado: (2015)

Corrigendum to “Diagnostic and predictive values of circulating tetrahydrobiopterin levels as a novel biomarker in patients with thoracic and abdominal aortic aneurysms” [Redox Biol. 56 (2022) 102444]
por: Zhang, Yixuan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_cpace4ltv901ei1rabtivft62c