TLR-adjuvanted nanoparticle vaccines differentially influence the quality and longevity of responses to malaria antigen Pfs25

Transmission-blocking vaccines (TBVs) are considered an integral element of malaria eradication efforts. Despite promising evaluations of Plasmodium falciparum Pfs25-based TBVs in mice, clinical trials have failed to induce robust and long-lived Ab titers, in part due to the poorly immunogenic natur...

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Detalles Bibliográficos
Autores principales: Thompson, Elizabeth A., Ols, Sebastian, Miura, Kazutoyo, Rausch, Kelly, Narum, David L., Spångberg, Mats, Juraska, Michal, Wille-Reece, Ulrike, Weiner, Amy, Howard, Randall F., Long, Carole A., Duffy, Patrick E., Johnston, Lloyd, O’Neil, Conlin P., Loré, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012510/
https://www.ncbi.nlm.nih.gov/pubmed/29769448
http://dx.doi.org/10.1172/jci.insight.120692

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6012510/
https://www.ncbi.nlm.nih.gov/pubmed/29769448
http://dx.doi.org/10.1172/jci.insight.120692

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