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Sequence characteristics define trade-offs between on-target and genome-wide off-target hybridization of oligoprobes

Off-target oligoprobe’s interaction with partially complementary nucleotide sequences represents a problem for many bio-techniques. The goal of the study was to identify oligoprobe sequence characteristics that control the ratio between on-target and off-target hybridization. To understand the compl...

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Detalles Bibliográficos
Autores principales: Matveeva, Olga V., Ogurtsov, Aleksey Y., Nazipova, Nafisa N., Shabalina, Svetlana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013149/
https://www.ncbi.nlm.nih.gov/pubmed/29928000
http://dx.doi.org/10.1371/journal.pone.0199162