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Sequence characteristics define trade-offs between on-target and genome-wide off-target hybridization of oligoprobes
Off-target oligoprobe’s interaction with partially complementary nucleotide sequences represents a problem for many bio-techniques. The goal of the study was to identify oligoprobe sequence characteristics that control the ratio between on-target and off-target hybridization. To understand the compl...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013149/ https://www.ncbi.nlm.nih.gov/pubmed/29928000 http://dx.doi.org/10.1371/journal.pone.0199162 |