Mitotic polarization of transcription factors during asymmetric division establishes fate of forming cancer cells

A model of K-Ras-initiated lung cancer was used to follow the transition of precancerous adenoma to adenocarcinoma. In hypoxic, Tgf-β1-rich interiors of adenomas, we show that adenoma cells divide asymmetrically to produce cancer-generating cells highlighted by epithelial mesenchymal transition and...

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Detalles Bibliográficos
Autores principales: Liu, Yongqing, Siles, Laura, Lu, Xiaoqin, Dean, Kevin C., Cuatrecasas, Miriam, Postigo, Antonio, Dean, Douglas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013470/
https://www.ncbi.nlm.nih.gov/pubmed/29930325
http://dx.doi.org/10.1038/s41467-018-04663-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013470/
https://www.ncbi.nlm.nih.gov/pubmed/29930325
http://dx.doi.org/10.1038/s41467-018-04663-1

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