Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis

Necroptotic cell death is mediated by the most terminal known effector of the pathway, MLKL. Precisely how phosphorylation of the MLKL pseudokinase domain activation loop by the upstream kinase, RIPK3, induces unmasking of the N-terminal executioner four-helix bundle (4HB) domain of MLKL, higher-ord...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrie, Emma J., Sandow, Jarrod J., Jacobsen, Annette V., Smith, Brian J., Griffin, Michael D. W., Lucet, Isabelle S., Dai, Weiwen, Young, Samuel N., Tanzer, Maria C., Wardak, Ahmad, Liang, Lung-Yu, Cowan, Angus D., Hildebrand, Joanne M., Kersten, Wilhelmus J. A., Lessene, Guillaume, Silke, John, Czabotar, Peter E., Webb, Andrew I., Murphy, James M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013482/
https://www.ncbi.nlm.nih.gov/pubmed/29930286
http://dx.doi.org/10.1038/s41467-018-04714-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013482/
https://www.ncbi.nlm.nih.gov/pubmed/29930286
http://dx.doi.org/10.1038/s41467-018-04714-7

Ejemplares similares