CXCL4/Platelet Factor 4 is an agonist of CCR1 and drives human monocyte migration

Activated platelets release micromolar concentrations of the chemokine CXCL4/Platelet Factor-4. Deposition of CXCL4 onto the vascular endothelium is involved in atherosclerosis, facilitating monocyte arrest and recruitment by an as yet, unidentified receptor. Here, we demonstrate that CXCL4 drives c...

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Detalles Bibliográficos
Autores principales: Fox, James M., Kausar, Fahima, Day, Amy, Osborne, Michael, Hussain, Khansa, Mueller, Anja, Lin, Jessica, Tsuchiya, Tomoko, Kanegasaki, Shiro, Pease, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013489/
https://www.ncbi.nlm.nih.gov/pubmed/29930254
http://dx.doi.org/10.1038/s41598-018-27710-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013489/
https://www.ncbi.nlm.nih.gov/pubmed/29930254
http://dx.doi.org/10.1038/s41598-018-27710-9

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