Development of a Novel Backbone Cyclic Peptide Inhibitor of the Innate Immune TLR/IL1R Signaling Protein MyD88

MyD88 is a cytoplasmic adaptor protein that plays a central role in signaling downstream of the TLRs and the IL1R superfamily. We previously demonstrated that MyD88 plays a critical role in EAE, the murine model of multiple sclerosis, and showed that the MyD88 BB-loop decoy peptide RDVLPGT ameliorat...

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Detalles Bibliográficos
Autores principales: Dishon, Shira, Schumacher, Adi, Fanous, Joseph, Talhami, Alaa, Kassis, Ibrahim, Karussis, Dimitrios, Gilon, Chaim, Hoffman, Amnon, Nussbaum, Gabriel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013495/
https://www.ncbi.nlm.nih.gov/pubmed/29930295
http://dx.doi.org/10.1038/s41598-018-27773-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013495/
https://www.ncbi.nlm.nih.gov/pubmed/29930295
http://dx.doi.org/10.1038/s41598-018-27773-8

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