The Glycolytic Metabolite, Fructose-1,6-bisphosphate, Blocks Epileptiform Bursts by Attenuating Voltage-Activated Calcium Currents in Hippocampal Slices

Manipulation of metabolic pathways (e.g., ketogenic diet (KD), glycolytic inhibition) alters neural excitability and represents a novel strategy for treatment of drug-refractory seizures. We have previously shown that inhibition of glycolysis suppresses epileptiform activity in hippocampal slices. I...

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Detalles Bibliográficos
Autores principales: Shao, Li-Rong, Wang, Guangxin, Stafstrom, Carl E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013557/
https://www.ncbi.nlm.nih.gov/pubmed/29962940
http://dx.doi.org/10.3389/fncel.2018.00168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013557/
https://www.ncbi.nlm.nih.gov/pubmed/29962940
http://dx.doi.org/10.3389/fncel.2018.00168

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