Rapid biocompatible macrocyclization of peptides with decafluoro-diphenylsulfone

In this manuscript, we describe modification of Cys-residues in peptides and proteins in aqueous solvents via aromatic nucleophilic substitution (S(N)Ar) with perfluoroarenes (fAr). Biocompatibility of this reaction makes it attractive for derivatization of proteins and peptide libraries comprised o...

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Detalles Bibliográficos
Autores principales: Kalhor-Monfared, S., Jafari, M. R., Patterson, J. T., Kitov, P. I., Dwyer, J. J., Nuss, J. M., Derda, R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013815/
https://www.ncbi.nlm.nih.gov/pubmed/30155020
http://dx.doi.org/10.1039/c5sc03856a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013815/
https://www.ncbi.nlm.nih.gov/pubmed/30155020
http://dx.doi.org/10.1039/c5sc03856a

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