Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency

BACKGROUND: Loss of function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD). Progranulin is a secreted glycoprotein that localizes to lysosomes and is critical for proper lysosomal function. Heterozygous GRN mutation carriers develop FTD with TDP-43 pathology and e...

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Detalles Bibliográficos
Autores principales: Arrant, Andrew E., Nicholson, Alexandra M., Zhou, Xiaolai, Rademakers, Rosa, Roberson, Erik D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013889/
https://www.ncbi.nlm.nih.gov/pubmed/29929528
http://dx.doi.org/10.1186/s13024-018-0264-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6013889/
https://www.ncbi.nlm.nih.gov/pubmed/29929528
http://dx.doi.org/10.1186/s13024-018-0264-6

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